Babraham Institute

Liston Lab

The Liston Lab works on the interface between regulatory T cells and the tissues, focussing on developing new tools to reveal novel biology.

LabListon on Twitter

The Systems Immunology Team focuses on understanding variation in the human immune system. The team runs our immune phenotyping platform and gene discovery program. The gene discovery program has lead to the identification of multiple new primary immunodeficiencies and inflammatory diseases, including the discovery of Pyrin-associated autoinflammation and neutrophilic dermatosis, treatments for the newly identified CECR1 (ADA2)-deficiency, identifying the immune component of Olmsted syndrome and identifying IFIH1 mutations as a cause for juvenile lupus. We also develop new models of Primary Immunodeficiency, such as the first model of leaky SCID, and use mouse models to unravel the mechanism of disease, such as Treg-deficiency in HLH.

Key papers:

Masters et al, Science Translational Medicine

Carr et al, Nature Immunology 2016

Humblet-Baron et al, Journal of Allergy and Clinical Immunology 2016

Liston and Masters, Nature Reviews Immunology 2016

This project was set-up with funding from the European Research Council (ERC Start Grant) and has been supported in the past by the FWOJeffrey Modell Foundation and the University of Leuven. This work is currently funded by the European Union Horizon2020 program. 

If you are worried that your child may have a primary immune deficiency, look here to see the warning signs.