James Dooley: Transforming clinical treatment of neuroinflammatory conditions

Listen to Dr James Dooley get interviewed on The Big Experiment, about life, science and business:

Imagine being able to internalise the pharmaceutical factory into the human.

You could avoid the contamination risks and need for purification in biologic production.

In this episode I am joined by Dr James Dooley who is doing just this with his work at Aila Biotech. James and his team developed technology to drive the production of immune-regulating biologics at the exact site of disease. Through precise spatial and temporal control over biologic expression, Aila Biotech can prevent neuroinflammatory damage in brain injury.

James discusses his journey into science and how this work began. As well as the challenges that come with having to focus on the business, not just the science. He also reflects on what he might do differently if he were to start again.

“We really think we can have a dramatic effect on people's quality of life long term” – James Dooley

You’ll hear about:

01:50 – James’ journey into science

06:52 – James on drug delivery by adeno associated viruses

13:26 - What's the specificity of infection?

19:38 - Is there an invisible downside?

23:32 – James on the challenges of focusing on the business

28:47 – Will James be taking the therapy into the clinic?

36:25 – Would James do anything differently next time?